Abstract |
Triple-negative breast cancer (TNBC) is a type of malignant and heterogeneous tumor in premenopausal females with ineffective therapeutic targets. IL-8 is one of the earliest discovered chemotaxis cytokines which expression is closely related to the progress of various cancers. Previous studies show that IL-8 determines the prognosis of TNBC patients, nevertheless how IL-8 influence the progress of TNBC is unclear. In our studies, we discovered that overexpression of IL-8 promotes TNBC cells (TNBCs) migration and tumor growth via the PI3K-Akt and MAPK signaling pathway. Cell-cycle of TNBCs arrest at S phase by overexpression of IL-8, however, there is no significant difference on the cell viability and cell apoptosis of TNBCs. Besides, overexpression of IL-8 result in the downregulation of E-cadherin and the upregulation of Cyclin B1 in MDA-MB-231 cells. Taken together, our results suggest that IL-8 plays a crucial role in the progress of TNBC, and it could be a novel therapeutic target of TNBC.
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Authors | Fang Deng, Yaguang Weng, Xian Li, Teng Wang, Mengtian Fan, Qiong Shi |
Journal | Pathology, research and practice
(Pathol Res Pract)
Vol. 223
Pg. 152824
(Jul 2021)
ISSN: 1618-0631 [Electronic] Germany |
PMID | 34000674
(Publication Type: Journal Article)
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Copyright | Copyright © 2021. Published by Elsevier GmbH. |
Chemical References |
- CXCL8 protein, human
- Interleukin-8
- Phosphatidylinositol 3-Kinase
- Proto-Oncogene Proteins c-akt
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Topics |
- Animals
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Epithelial-Mesenchymal Transition
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Interleukin-8
(genetics, metabolism)
- Mice, Nude
- Neoplasm Invasiveness
- Phosphatidylinositol 3-Kinase
(metabolism)
- Proto-Oncogene Proteins c-akt
(metabolism)
- S Phase Cell Cycle Checkpoints
- Signal Transduction
- Triple Negative Breast Neoplasms
(enzymology, genetics, pathology)
- Tumor Burden
- Up-Regulation
- Mice
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