The effects of nondigestible fermentable carbohydrates on adults with overweight or obesity: a meta-analysis of randomized controlled trials.

Abstract

CONTEXT:

Nondigestible fermentable carbohydrates (NDFCs) can be fermented by microbiota, thereby yielding metabolites that have a beneficial role in the prevention and treatment of obesity and its complications. However, to our knowledge, no meta-analysis has been conducted to evaluate the effects of NDFCs on obesity.

OBJECTIVE:

To conduct a meta-analysis of randomized controlled trials (RCTs) to summarize existing evidence on the effects of numerous NDFCs on adiposity and cardiovascular risk factors in adults with overweight or obesity with ≥2 weeks of follow-up.

DATA SOURCES:

The following databases were searched: MEDLINE, Embase, and CINAHL.

DATA EXTRACTION:

Seventy-seven RCTs with 4535 participants were identified for meta-analysis from the 3 databases.

DATA ANALYSIS:

The findings suggest that increased intake of NDFCs is significantly effective in reducing body mass index by 0.280 kg/m2, weight by 0.501 kg, hip circumference by 0.554 cm, waist circumference by 0.649 cm, systolic blood pressure by 1.725 mmHg, total cholesterol by 0.36 mmol/L, and low-density lipoprotein by 0.385 mmol/L, with evidence of moderate-to-high quality.

CONCLUSION:

Convincing evidence from meta-analyses of RCTs indicates that increased NDFC intake improves adiposity, blood lipid levels, and systolic blood pressure in people with overweight and obesity.

• Authors: Bocheng Xu, Jinping Cao, Jie Fu, Zhi Li, Mingliang Jin, Xinxia Wang, Yizhen Wang
• Journal: Nutrition reviews (Nutr Rev) Vol. 80 Issue 2 Pg. 165-177 (01 10 2022) ISSN: 1753-4887 [Electronic] United States
• PMID: 33997907 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Carbohydrates

Topics

• Adult
• Body Weight
• Carbohydrates
• Humans
• Obesity (therapy)
• Overweight (therapy)
• Randomized Controlled Trials as Topic