Abstract | PURPOSE: METHODS: Among 178 patients, 43.5% developed grade ≥ 2 PCE. Clinical and dosimetric factors associated with PCE or overall survival (OS) were identified via multi-variable Cox proportional hazards modeling. The Voxel-Based Analyses (VBAs) of local dose differences between patients with and without PCE and mortality was performed. The robustness of VBA results was assessed by a novel characterization of spatial properties of dose distributions based on probabilistic independent component analysis ( PICA) and connectograms. RESULTS: Several non-dosimetric variables were selected by the multivariable analysis for the considered outcomes, while the time-dependent PCE onset was uncorrelated with the OS (p = 0.34) at a multi-variable Cox analysis. Despite the significant PSPT dosimetric advantage, the RT technique did not affect the occurrence of PCE or OS. VBAs highlighted largely overlapping clusters significantly associated with PCE endpoints in heart and lungs. No significant dosimetric patterns related to mortality endpoints were found. PICA identified 43 components homogeneously scattered within thorax, while connectograms showed modest correlations between doses in main cardio-pulmonary substructures. CONCLUSIONS: Spatially resolved analysis highlighted dose patterns related to radiation-induced cardiac toxiciy and the observed organ-based dose-response mismatch in PSPT and IMRT. Indeed, the thoracic regions spared by PSPT poorly overlapped with the areas involved in PCE development, as highlited by VBA. PICA and connectograms proved valuable tools for assessing the robusteness of obtained VBA inferences.
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Authors | Laura Cella, Serena Monti, Ting Xu, Raffaele Liuzzi, Arnaldo Stanzione, Marco Durante, Radhe Mohan, Zhongxing Liao, Giuseppe Palma |
Journal | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
(Radiother Oncol)
Vol. 160
Pg. 148-158
(07 2021)
ISSN: 1879-0887 [Electronic] Ireland |
PMID | 33979653
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2021 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Carcinoma, Non-Small-Cell Lung
(radiotherapy)
- Humans
- Lung Neoplasms
(radiotherapy)
- Pericardial Effusion
(etiology)
- Photons
- Proton Therapy
(adverse effects)
- Protons
- Radiotherapy Dosage
- Radiotherapy, Intensity-Modulated
(adverse effects)
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