Pretreatment CT and PET radiomics predicting rectal cancer patients in response to neoadjuvant chemoradiotherapy.

Abstract

BACKGROUND:

The purpose of this study was to characterize pre-treatment non-contrast computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography (PET) based radiomics signatures predictive of pathological response and clinical outcomes in rectal cancer patients treated with neoadjuvant chemoradiotherapy (NACR T).

MATERIALS AND METHODS:

An exploratory analysis was performed using pre-treatment non-contrast CT and PET imaging dataset. The association of tumor regression grade (TRG) and neoadjuvant rectal (NAR) score with pre-treatment CT and PET features was assessed using machine learning algorithms. Three separate predictive models were built for composite features from CT + PET.

RESULTS:

The patterns of pathological response were TRG 0 (n = 13; 19.7%), 1 (n = 34; 51.5%), 2 (n = 16; 24.2%), and 3 (n = 3; 4.5%). There were 20 (30.3%) patients with low, 22 (33.3%) with intermediate and 24 (36.4%) with high NAR scores. Three separate predictive models were built for composite features from CT + PET and analyzed separately for clinical endpoints. Composite features with α = 0.2 resulted in the best predictive power using logistic regression. For pathological response prediction, the signature resulted in 88.1% accuracy in predicting TRG 0 vs. TRG 1-3; 91% accuracy in predicting TRG 0-1 vs. TRG 2-3. For the surrogate of DFS and OS, it resulted in 67.7% accuracy in predicting low vs. intermediate vs. high NAR scores.

CONCLUSION:

The pre-treatment composite radiomics signatures were highly predictive of pathological response in rectal cancer treated with NACR T. A larger cohort is warranted for further validation.

• Authors: Zhigang Yuan, Marissa Frazer, Anupam Rishi, Kujtim Latifi, Michal R Tomaszewski, Eduardo G Moros, Vladimir Feygelman, Seth Felder, Julian Sanchez, Sophie Dessureault, Iman Imanirad, Richard D Kim, Louis B Harrison, Sarah E Hoffe, Geoffrey G Zhang, Jessica M Frakes
• Journal: Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology (Rep Pract Oncol Radiother) Vol. 26 Issue 1 Pg. 29-34 ( 2021) ISSN: 1507-1367 [Print] Poland
• PMID: 33948299 (Publication Type: Journal Article)
• Copyright: © 2021 Greater Poland Cancer Centre.