Abstract | BACKGROUND: Mesenchymal sarcomas are tumors that originate from mesenchymal tissue. Most mesenchymal sarcomas can be accurately classified, but some are unclassifiable in clinical practice. Molecular detection methods enable patients to benefit from molecular-targeted therapies for many cancers, including lung, breast, and bowel cancers. Further, even unclassified tumors can have therapeutic targets. NTRK gene fusions are sporadic genetic alterations that occur across tumor entities. If NTRK gene fusions are detected, TRK inhibitors can be used regardless of the tumor entity. CASE PRESENTATION: CONCLUSIONS: This case will be of significant interest to pathologists because, despite the tumor being unclassified, a molecular target was identified. Although the FDA does not currently approve crizotinib for treatment of patients harboring NTRK gene fusions, this case provides new insights for diagnosis and treatment of mesenchymal sarcomas with NTRK1 gene translocations. Similar to ALKomas, which can be successfully treated using NTRK molecular-targeted therapy, tumors with NTRK gene translocations can be classified as NTRKomas, even when they occur at different organ sites, and with varying histological morphologies, and immunophenotypes.
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Authors | Weijie Chen, Huimei Wang, Dongxian Jiang, Lijuan Luan, Yuhong Zhou, Yingyong Hou |
Journal | World journal of surgical oncology
(World J Surg Oncol)
Vol. 19
Issue 1
Pg. 136
(Apr 30 2021)
ISSN: 1477-7819 [Electronic] England |
PMID | 33941195
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Adaptor Proteins, Signal Transducing
- DNA-Binding Proteins
- KHDRBS1 protein, human
- Oncogene Proteins, Fusion
- RNA-Binding Proteins
- Crizotinib
- Receptor, trkA
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Topics |
- Adaptor Proteins, Signal Transducing
- Crizotinib
(therapeutic use)
- DNA-Binding Proteins
- Gene Fusion
- Humans
- Neoplasm Recurrence, Local
- Oncogene Proteins, Fusion
(genetics)
- Prognosis
- RNA-Binding Proteins
- Receptor, trkA
(genetics)
- Sarcoma
(drug therapy, genetics)
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