Abstract | BACKGROUND:
Immune checkpoint blockade (ICB) therapy has yielded successful clinical responses in treatment of a minority of patients in certain cancer types. Substantial efforts were made to establish biomarkers for predicting responsiveness to ICB. However, the systematic assessment of these ICB response biomarkers remains insufficient. METHODS: We collected 22 transcriptome-based biomarkers for ICB response and constructed multiple benchmark datasets to evaluate the associations with clinical response, predictive performance, and clinical efficacy of them in pre-treatment patients with distinct ICB agents in diverse cancers. RESULTS: CONCLUSIONS: Our results show these biomarkers had different performance in predicting ICB response across distinct ICB agents in diverse cancers.
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Authors | Shangqin Sun, Liwen Xu, Xinxin Zhang, Lin Pang, Zhilin Long, Chunyu Deng, Jiali Zhu, Shuting Zhou, Linyun Wan, Bo Pang, Yun Xiao |
Journal | Cancers
(Cancers (Basel))
Vol. 13
Issue 7
(Apr 01 2021)
ISSN: 2072-6694 [Print] Switzerland |
PMID | 33915876
(Publication Type: Journal Article)
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