COVID-19 has become the biggest public health problem and one of the most important causes of death in many countries in the world.
SARS-CoV-2 infection is most likely to be fatal in elderly patients with concomitant diseases. In this article we present two cases of asymptomatic SARS-CoV-2-positive patients suffering from
cancer who were treated with
chemotherapy. The first case, a patient with primary mediastinal
B-cell lymphoma, shows that confirmed
SARS-CoV-2 infection does not have to be a
contraindication to
chemotherapy. We describe the course of disease and discuss doubts related to the choice of
chemotherapy regimen. The second patient was a male with metastatic
sigmoid cancer treated with FOLFOX4 as first-line palliative
chemotherapy. This case draws attention to asymptomatic SARS-CoV-2 carriers who underwent
chemotherapy. Our patient was safely treated with
chemotherapy without long break caused by
viral infection. It should be remembered that there are asymptomatic carriers among
cancer patients and that they may spread
infection to others. On the other hand, delaying
chemotherapy can cause rapid
disease progression and reduce overall survival of our patients.