Abstract | BACKGROUND: METHODS: PubMed, Web of Science, EMBASE, and Ovid databases were searched for relevant studies published. We performed both fixed- and random-effects meta-analyses of the changes in blood pressure, estimated glomerular filtration rate (eGFR), and urinary albumin-to- creatinine ratio (UACR) after RDN. RESULTS: The meta-analysis included 238 patients from 11 single-center, non-randomized, uncontrolled studies. Office blood pressure and 24-hour ambulatory blood pressure (24 h-ABP) showed a significant reduction 1 month after RDN (p < 0.05). This decrease of 24 h-ABP persisted for 24 months after RDN showed difference systolic blood pressure (p < 0.001) and diastolic blood pressure (p = 0.001). The 24 h-ABP exhibited a similar trend in the subgroup analysis. eGFR measurements obtained at each time point of analysis after RDN were not significantly different from those obtained before (p > 0.05). UACR levels were significantly reduced at 3 months and 6 months after RDN (p < 0.001). After RDN, the heart rate showed no significant changes (p > 0.05), and few major complications were encountered. CONCLUSIONS: The meta-analysis showed that RDN may be effective and safe for treating CKD patients with hypertension. Well-designed randomized controlled trials of RDN are urgently needed to confirm the safety and reproducibility of RDN and to assess its impact on clinical outcomes.
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Authors | Mengdi Xia, Tong Liu, Dongming Chen, Ying Huang |
Journal | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
(Int J Hyperthermia)
Vol. 38
Issue 1
Pg. 732-742
( 2021)
ISSN: 1464-5157 [Electronic] England |
PMID | 33908329
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Topics |
- Blood Pressure Monitoring, Ambulatory
- Denervation
- Humans
- Hypertension
(surgery)
- Kidney
(surgery)
- Renal Insufficiency, Chronic
(therapy)
- Reproducibility of Results
- Treatment Outcome
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