Tumor induction in mice administered neonatally with 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole or 2-amino-dipyrido[1,2-a:3',2'-d]imidazole.

Abstract

The tumorigenic effects of 2 L-glutamic acid pyrolysates to ICR mice were studied. The newborn animals received subcutaneously either 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) or 2-amino-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2). The mice were observed for 1 year. The tumors of the lung and liver were induced. Statistical analysis revealed that the incidences of the lung tumor in the mice given Glu-P-1 or Glu-P-2 and that of liver tumor in the male mice given Glu-P-2 25 mg/kg body wt were significantly higher than those of controls.

• Authors: K Fujii, A Sakai, K Nomoto, K Nakamura
• Journal: Cancer letters (Cancer Lett) Vol. 41 Issue 1 Pg. 75-80 (Jul 1988) ISSN: 0304-3835 [Print] Ireland
• PMID: 3390804 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Imidazoles
• Mutagens
• 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole
• Glu-P-2

Topics

• Animals
• Animals, Newborn
• Female
• Imidazoles (toxicity)
• Liver Neoplasms, Experimental (chemically induced)
• Lung Neoplasms (chemically induced)
• Lymphoma (chemically induced)
• Male
• Mice
• Mice, Inbred ICR
• Mutagens
• Neoplasms, Experimental (chemically induced)