Pancreatic cancer is one of the most aggressive
tumors with poor prognosis and new targetable
therapies are urgently required. CSE1L (chromosome segregation 1 like) is thought to play an important role in
tumorigenesis and acts as a
cancer therapeutic target. However, the
biological function and the underlying mechanism of CSE1L in
pancreatic cancer are still not fully explicit. In the present study, we found that high CSE1L expression was related to a worse prognosis in patients with
pancreatic cancer according to data from the
Cancer Genome Atlas (TCGA) database. Additionally, we found that CSE1L knockdown inhibited the proliferation of
pancreatic cancer cells and promoted apoptosis, while CSE1L overexpression demonstrated the opposite phenomenon. Furthermore, we discovered that CSE1L might regulate
pancreatic cancer proliferation through AKT signaling pathway. In summary, we reveal that CSE1L plays a crucial role in
tumor growth and may serve as a potential prognostic and therapeutic target for
pancreatic cancer.