Dual Functional Pd-Catalyzed Multicomponent Reaction by Umpolung Chemistry of the Oxygen Atom in Electrophiles.

Abstract

A Pd-catalyzed multicomponent reaction was developed by trapping oxomium ylide with nitrosobenzene via Pd-promoted umpolung chemistry. The Pd catalyst plays two important roles: diazo compound decomposed catalyst and Lewis acid for the activation of nitrosobenzene. This strategy provides some insight into a new way for discovery of multicomponent methodology to construct complex molecules. The developed method also provides rapid access to a series of O-(2-oxy) hydroxylamine derivatives, which exhibit good anticancer activity in osteosarcoma cells.

• Authors: Wangyujing Han, Jie Yu, Zhenghui Kang, Longlong Song, Rou Pi, Suzhen Dong, Yuqing Xiong, Fei Xia, Zi Li, Shunying Liu
• Journal: The Journal of organic chemistry (J Org Chem) Vol. 86 Issue 9 Pg. 6847-6854 (05 07 2021) ISSN: 1520-6904 [Electronic] United States
• PMID: 33844915 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lewis Acids
• Palladium
• Oxygen

Topics

• Catalysis
• Lewis Acids
• Oxygen
• Palladium