Abstract |
Psychological stress is a common etiology among patients with lung cancer and serves as a potential indication of poor prognosis and advanced cancer clinical stage. Evidence indicates that depression is positively correlated with the evolvement of lung carcinoma. Nevertheless, the mechanisms underlying the effects of mental disorder on lung cancer have not been considerably and systemically explored. We hypothesized that mental disorder may affect the adjustment of the tumor microenvironment and immune cells. We used the chronic unpredictable mild stress (CUMS) procedure to induce depressed mice models and established tumor-bearing models of C57BL/6 J mice. Results revealed that the worsening of lung cancer was notably hastened in the CUMS + tumor group. Notably, the expression of PD-L1 in tumor issues increased in the tumor microenvironment, accompanied with a decline in the levels of CD8. On the basis of the date of tumor migration, our results indicated that MMPs and VEGF significantly increased after CUMS + tumor treatment. Thus, we demonstrated that modulation of the tumor microenvironment is pivotal for depression-promoted lung cancer migration.
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Authors | Sainan Cui, Huiyuan Lin, Yongfei Cui, Wenhao Wen, Xulan Cui, Chongkun Shen, Haixin Mo, Lei Yang, Shasha Bai, Yafei Shi, Rong Zhang |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 754
Pg. 135851
(05 29 2021)
ISSN: 1872-7972 [Electronic] Ireland |
PMID | 33781910
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 Elsevier B.V. All rights reserved. |
Chemical References |
- Antidepressive Agents
- B7-H1 Antigen
- Cd274 protein, mouse
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Topics |
- Animals
- Antidepressive Agents
(administration & dosage)
- B7-H1 Antigen
(metabolism)
- Carcinoma, Lewis Lung
(immunology, prevention & control, psychology, secondary)
- Cell Line, Tumor
- Depression
(complications, drug therapy, immunology, psychology)
- Disease Progression
- Humans
- Lung
(immunology, pathology)
- Lung Neoplasms
(immunology, pathology, prevention & control, psychology)
- Male
- Mice
- Mice, Inbred C57BL
- Stress, Psychological
(complications, immunology, psychology)
- T-Lymphocytes, Cytotoxic
- Tumor Microenvironment
(drug effects, immunology)
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