Abstract | OBJECTIVE: METHODS: Based on the perspective Wenzhou Birth Cohort, this nested case-control study included 101 fetal growth restriction (FGR) and 101 healthy newborns. Maternal serum samples were collected during the third trimester and measured for PBDEs by gas chromatography tandem mass spectrometry. The basic information of mother-newborn pairs was collected from questionnaires, whereas the placental size and birth outcomes of newborns were obtained from hospital records. RESULTS: A total of 19 brominated diphenyle ether (BDE) congeners were detected in maternal serum samples. Higher concentrations of BDE-207, -208, -209, and ∑ 19PBDEs were detected in FGR cases than in controls. Increased BDE-207, -208, -209, and ∑ 19PBDEs levels in maternal serum were related to decreased placental length, breadth, surface area, birth weight, birth length, gestational age, and Quetelet index of newborns. After adjusting for confounders, BDE-207 and ∑ 19PBDE concentrations in maternal serum were significantly associated with an increased risk of FGR. CONCLUSION: A negative association was found between PBDE levels in maternal serum and placental size and birth outcomes. Prenatal PBDE exposure may be associated with elevated risk of the incidence of FGR birth.
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Authors | Yu Ting Jin, Xiao Kai Deng, Ying Ya Zhao, Jia Lin Li, Qi Song, Yun Hui Zhang, Qing Yang, Shang Qin Chen |
Journal | Biomedical and environmental sciences : BES
(Biomed Environ Sci)
Vol. 33
Issue 11
Pg. 821-828
(Nov 20 2020)
ISSN: 2214-0190 [Electronic] China |
PMID | 33771235
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved. |
Chemical References |
- Halogenated Diphenyl Ethers
- pentabromodiphenyl ether
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Topics |
- Case-Control Studies
- China
(epidemiology)
- Female
- Fetal Growth Retardation
(chemically induced, epidemiology)
- Halogenated Diphenyl Ethers
(blood)
- Humans
- Incidence
- Infant, Newborn
- Placenta
(physiology)
- Pregnancy
- Risk Factors
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