Hypoxia modulation by dual-drug nanoparticles for enhanced synergistic sonodynamic and starvation therapy.

Abstract

BACKGROUND:

Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. In this work, multifunctional theranostic nanoparticles (NPs) were synthesized for synergistic starvation therapy and SDT by loading glucose oxidase (GOx, termed G) and 5,10,15,20-tetrakis (4-chlorophenyl) porphyrin) Cl (T (p-Cl) PPMnCl, termed PMnC) in Poly (lactic-co-glycolic) acid (PLGA) NPs (designated as MG@P NPs).

RESULTS:

On account of the peroxidase-like activity of PMnC, MG@P NPs can catalyze hydrogen peroxide (H2O2) in tumor regions to produce oxygen (O2), thus enhancing synergistic therapeutic effects by accelerating the decomposition of glucose and promoting the production of cytotoxic singlet oxygen (1O2) induced by ultrasound (US) irradiation. Furthermore, the NPs can also serve as excellent photoacoustic (PA)/magnetic resonance (MR) imaging contrast agents, effectuating imaging-guided cancer treatment.

CONCLUSION:

Multifunctional MG@P NPs can effectuate the synergistic amplification effect of cancer starvation therapy and SDT by hypoxia modulation, and act as contrast agents to enhance MR/PA dual-modal imaging. Consequently, MG@P NPs might be a promising nano-platform for highly efficient cancer theranostics.

• Authors: Jingxue Wang, Ju Huang, Weichen Zhou, Jiawen Zhao, Qi Peng, Liang Zhang, Zhigang Wang, Pan Li, Rui Li
• Journal: Journal of nanobiotechnology (J Nanobiotechnology) Vol. 19 Issue 1 Pg. 87 (Mar 26 2021) ISSN: 1477-3155 [Electronic] England
• PMID: 33771168 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Blood Glucose
• Pharmaceutical Preparations
• Hydrogen Peroxide
• Oxygen

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Blood Glucose
• Cell Line, Tumor
• Containment of Biohazards
• Female
• Humans
• Hydrogen Peroxide
• Hypoxia (drug therapy)
• Magnetic Resonance Imaging
• Mice, Inbred BALB C
• Nanomedicine (methods)
• Nanoparticles (chemistry, therapeutic use)
• Oxygen
• Pharmaceutical Preparations
• Starvation
• Mice