Abstract | BACKGROUND: METHODS: RESULTS: PIM447 significantly decreased the viability, proliferation, and motility of HuH6 and COA67 cells. Apoptosis significantly increased following PIM447 treatment. PIM447 had a significant impact on tumor cell stemness as evidenced by decreased expression of CD133 and reduced ability of HuH6 and COA67 cells to form tumorspheres. Furthermore, combining PIM447 with cisplatin resulted in a significant decrease in cell viability compared to either treatment alone. CONCLUSION:
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Authors | Nikita Wadhwani, Hooper R Markert, Raoud Marayati, Laura V Bownes, Colin H Quinn, Jamie M Aye, Jerry E Stewart, Karina J Yoon, Elizabeth A Beierle |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 56
Issue 6
Pg. 1157-1164
(Jun 2021)
ISSN: 1531-5037 [Electronic] United States |
PMID | 33762119
(Publication Type: Journal Article)
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Copyright | Copyright © 2021. Published by Elsevier Inc. |
Chemical References |
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Topics |
- Apoptosis
- Cell Line, Tumor
- Cell Proliferation
- Cell Transformation, Neoplastic
- Cisplatin
(pharmacology)
- Hepatoblastoma
(drug therapy, genetics)
- Humans
- Liver Neoplasms
(drug therapy)
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