68Ga-FAPI PET/CT in Thyroid Cancer With Thyroglobulin Elevation and Negative Iodine Scintigraphy.

Abstract

ABSTRACT:

Differentiated thyroid cancer with thyroglobulin elevation and negative iodine scintigraphy (TENIS) syndrome is a diagnostic and therapy dilemma. In this study, we present a case of TENIS with detectable metastases in the larynx and lung on the CT scan. 68Ga-fibroblast activation protein inhibitor (FAPI) PET/CT was performed for further detection of tumor recurrence and metastases, which showed intense 68Ga-FAPI activity in the metastatic lesions. To the best of our knowledge, this is the first case of TENIS presenting with FAPI-avid metastatic lesions, demonstrating its usefulness for localizing recurrent or metastatic lesions in patients with TENIS.

• Authors: Hao Fu, Jie Fu, Jingxiong Huang, Xinyi Su, Haojun Chen
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 46 Issue 5 Pg. 427-430 (May 01 2021) ISSN: 1536-0229 [Electronic] United States
• PMID: 33661204 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• 68Ga-FAPI
• Iodine Radioisotopes
• Quinolines
• Thyroglobulin

Topics

• Adult
• Female
• Humans
• Iodine Radioisotopes
• Male
• Middle Aged
• Positron Emission Tomography Computed Tomography
• Quinolines
• Thyroglobulin (metabolism)
• Thyroid Neoplasms (diagnostic imaging, metabolism)