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Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening.

Abstract
Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms. This retrospective study enrolled a total of 758 patients who underwent both FIT and total colonoscopy. The effect of antithrombotic drugs on FIT accuracy in detecting colorectal neoplasms (CN), including colorectal cancer (CRC), advanced adenoma (AA), and non-advanced adenoma (NAA), was examined. Of the 758 patients, 144 (19%) received antithrombotic drugs (administration group). In administration group, 61/144 (42%) cases had CN [CRC:14, AA:15, NAA:32] and 217/614 (35%) cases had CN (CRC:43, AA:56, NAA:118) in non-administration group. The prevalence of CN was not significantly different between the two groups (p = 0.1157). There was no significant difference in sensitivity or specificity of the detection of all types of CN with or without taking antithrombotic drugs. Neither the positive predictive value nor negative predictive value of FIT was affected by antithrombotic drug administration. Taking antithrombotic drugs may not have a large impact on sensitivity, specificity, positive predictive value, or negative predictive value of FIT in screening for CN.
AuthorsTakashi Ibuka, Seiji Adachi, Yohei Horibe, Tomohiko Ohno, Masatoshi Mabuchi, Yusuke Suzuki, Osamu Yamauchi, Eri Takada, Midori Iwama, Koshiro Saito, Masamichi Arao, Koji Takai, Hiroshi Araki, Masahito Shimizu
JournalScientific reports (Sci Rep) Vol. 11 Issue 1 Pg. 4348 (02 23 2021) ISSN: 2045-2322 [Electronic] England
PMID33623065 (Publication Type: Journal Article)
Chemical References
  • Fibrinolytic Agents
Topics
  • Adenoma (epidemiology, prevention & control)
  • Aged
  • Aged, 80 and over
  • Colorectal Neoplasms (epidemiology, prevention & control)
  • Female
  • Fibrinolytic Agents (administration & dosage)
  • Humans
  • Immunologic Tests (standards, statistics & numerical data)
  • Male
  • Mass Screening (standards, statistics & numerical data)
  • Middle Aged
  • Occult Blood
  • Prevalence
  • Sensitivity and Specificity

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