Objective: Retrospective analysis was used to determine the population diagnosed with EGC, and HP
infection was used as the cut-off point to further evaluate the correlation between helicobacter pylori (HP)
infection and
tumor biological characteristics of early
gastric cancer (EGC). Methods: All cases were collected from patients diagnosed with EGC through endoscopic surgery or
surgical procedures from January 2009 to October 2018. General information,
tumor site,
tumor pathology, HER2 immunohistochemical results, and degree of HP
infection were collected for retrospective analysis. Results: A total of 111 cases were collected in this study. Among the HP negative group, there were statistically significant differences in
tumor sites between the uninfected group and the previously infected group (P<0.05).There were significant differences in monocyte infiltration and neutrophil infiltration between the positive and negative groups (P<0.05).The differentiated
adenocarcinoma in the positive group was significantly lower than that in the negative group. The incidence rate of Mixed type
cancer was significantly higher than that in the positive group (P<0.01). In the positive group of HP, there was a statistically significant difference in HER2 between the unsterilized group and the previously sterilized group (P<0.05).There was a statistically significant difference in HER2 between the HP positive group and the HP negative group (P<0.01). HP
infection was significantly correlated with HER2 index and presented a positive correlation (P=0.014). Conclusion: HP
infection is related to the
tumor site and mucosal inflammatory infiltration of EGC. The malignant degree of EGC complicated with HP
infection is higher, and most of them are mixed type. The degree of HP
infection was positively correlated with the degree of invasion and
malignancy of ECG. Furthermore, the
tumor indicator HER2 is closely related to HP
infection, and the detection of HP combined with HER2 is of great significance in the discovery of EGC and the evaluation of its
malignancy.