Abstract | OBJECTIVE: This study investigates the therapeutic potential of a small molecule inhibitor of plasminogen activator inhibitor-1 (PAI-1), TM5441, in reversing diet-induced obesity in mice. METHODS: Wild-type C57BL/6J mice were fed a high-fat high- sugar (HFHS) diet for 8 weeks to induce obesity. After the first 8 weeks, TM5441 was added to the diet for an additional 8 weeks. In order to determine the efficacy of PAI-1 inhibition in conjunction with dietary modification, mice were fed an HFHS diet for 8 weeks to induce obesity and were then switched to a low-fat diet with or without TM5441 for an additional 2 to 8 weeks. RESULTS: CONCLUSIONS: Pharmacologic PAI-1 inhibition stimulates adipose tissue lipolysis and enhances weight loss in obese mice.
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Authors | Joshua A Levine, Shantel Olivares, Toshio Miyata, Douglas E Vaughan, Anne S Henkel |
Journal | Obesity (Silver Spring, Md.)
(Obesity (Silver Spring))
Vol. 29
Issue 4
Pg. 713-720
(04 2021)
ISSN: 1930-739X [Electronic] United States |
PMID | 33594826
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 The Obesity Society. |
Chemical References |
- Plasminogen Activator Inhibitor 1
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Topics |
- Animals
- Lipolysis
(physiology)
- Male
- Mice
- Mice, Obese
- Plasminogen Activator Inhibitor 1
(therapeutic use)
- Weight Loss
(drug effects)
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