Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study.

Abstract

ABSTRACT:

Coronavirus disease 2019 (COVID-19) becomes a global pandemic in 2020. Early identification of severe ill patients is a top priority for clinicians. We aimed to describe clinical features and risk factors of severe-critically ill patients with COVID-19 in Jiangsu Province.This multi-centered retrospective study collected the information of 631 laboratory-confirmed COVID-19 patients hospitalized at 28 authorized hospitals in Jiangsu province from January 23, 2019 to March 13, 2020.A total of 583 adult patients with laboratory-confirmed COVID-19 were enrolled for final analysis, including 84 severe-critically ill patients and 499 mild-moderate patients. Median age of the severe-critically ill patients was 57.0 years old (interquartile range, 49.0-65.8), and 50 (59.5%) were males. Multisystemic laboratory abnormalities were observed on admission for severe-critically ill patients. These patients showed more noticeable radiologic abnormalities and more coexisting health issues as compared to the mild-moderate patients. Most of the severe-critically ill COVID-19 patients became deteriorated in 2 weeks after diagnosis. Age, D-dimer, and lymphocytes were independently associated with the progression of severe-critically illness.Older age, higher D-dimer levels and less lymphocyte counts on admission are potential risk factors for COVID-19 patients to develop into severe and critically illness.

• Authors: Jiangnan Zhao, Meiying Zhu, Xin Su, Mao Huang, Yi Yang, Jianan Huang, Ni Songshi, Quan Cao, Qin Gu, Jun Li, Jiashu Li, Wenjing Zhao, Bin Shi, Yi Shi
• Journal: Medicine (Medicine (Baltimore)) Vol. 100 Issue 5 Pg. e24332 (Feb 05 2021) ISSN: 1536-5964 [Electronic] United States
• PMID: 33592878 (Publication Type: Journal Article, Multicenter Study)
• Copyright: Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

Chemical References

• Fibrin Fibrinogen Degradation Products
• fibrin fragment D

Topics

• Age Factors
• COVID-19 (blood, physiopathology)
• China (epidemiology)
• Critical Illness (therapy)
• Disease Progression
• Female
• Fibrin Fibrinogen Degradation Products (analysis)
• Hospitalization (statistics & numerical data)
• Humans
• Lymphocyte Count (methods, statistics & numerical data)
• Male
• Middle Aged
• Retrospective Studies
• Risk Factors
• SARS-CoV-2 (isolation & purification, pathogenicity)
• Severity of Illness Index
• Symptom Assessment (statistics & numerical data)