Cell type-specific microRNA therapies for myocardial infarction.

Abstract

Current interventions fail to recover injured myocardium after infarction and prompt the need for development of cardioprotective strategies. Of increasing interest is the therapeutic use of microRNAs to control gene expression through specific targeting of mRNAs. In this Review, we discuss current microRNA-based therapeutic strategies, describing the outcomes and limitations of key microRNAs with a focus on target cell types and molecular pathways. Last, we offer a perspective on the outlook of microRNA therapies for myocardial infarction, highlighting the outstanding challenges and emerging strategies.

• Authors: Bohao Liu, Bryan Wang, Xiaokan Zhang, Roberta Lock, Trevor Nash, Gordana Vunjak-Novakovic
• Journal: Science translational medicine (Sci Transl Med) Vol. 13 Issue 580 (02 10 2021) ISSN: 1946-6242 [Electronic] United States
• PMID: 33568517 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)
• Copyright: Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Chemical References

• MicroRNAs

Topics

• Humans
• MicroRNAs (genetics)
• Myocardial Infarction (genetics, therapy)
• Myocardium