Abstract |
The therapeutic effect of cis-1, 1-cyclobutane dicarboxylato-(2R)-2-methyl-1,4-butane diamine platinum (II) ( NK 121) on 3 human yolk sac tumors of the ovary (YST-1, YST-2 and YST-3), which were transplanted into nude mice, was compared with that of cisplatin (CDDP). While tumors YST-2 and YST-3 exhibited a broad comparable sensitivity to CDDP and NK 121, YST-1 was substantially more sensitive to CDDP than NK 121. A significant weight loss was noted in the non- tumor bearing nude mice treated with CDDP, as compared with the loss in both control and NK 121-treated groups. NK 121 showed a good antitumor activity without showing severe toxicities.
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Authors | M Sawada, M Ozaki, H Taniguchi, R Tateishi, Y Mori, K Mino |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 15
Issue 4 Pt 1
Pg. 637-41
(Apr 1988)
ISSN: 0385-0684 [Print] Japan |
PMID | 3355185
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Organoplatinum Compounds
- NK 121
- Carboplatin
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Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Carboplatin
(analogs & derivatives)
- Female
- Humans
- Mesonephroma
(drug therapy, pathology)
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Organoplatinum Compounds
(therapeutic use)
- Ovarian Neoplasms
(drug therapy, pathology)
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