Unilateral Tnm T1 And T2 Papillary Thyroid Carcinoma With Lateral Cervical Lymph Node Metastasis: Total Thyroidectomy or Lobectomy?

Abstract

OBJECTIVE:

The aim of this study was to explore the effect of total thyroidectomy (TT) and lobectomy (LT) on the prognosis of unilateral papillary thyroid carcinoma (PTC) with lateral cervical lymph node metastasis.

METHODS:

Patients with PTC and lateral cervical lymph node metastasis who underwent lateral cervical lymph node dissection between January 2007 and December 2016 were retrospectively reviewed. To investigate the effect of surgical procedure on the prognosis of lymph node metastasis patients, other high-risk factors such as extrathyroidal invasion and large tumor size were excluded. All patients were in Tumor-Node-Metastasis (TNM) stage T1 and T2. Primary end point was recurrence-free survival (RFS).

RESULTS:

Among 264 PTC patients, 104 (39.4%) patients received TT and 160 (60.6%) patients received LT. With a median follow-up of 50 months (interquartile range, 34 to 74 months), 7 patients (2.65%) experienced recurrence. The 5-year RFS in the TT and LT groups was 96.1% and 97.7%, respectively, and was not significantly different (P = .765). Similar results were found when excluding patients who received radioiodine ablation, which were 97.7% and 97.4%, respectively (P = .752). Age ≥55 years (hazard ratio, 7.368; P = .018) and multifocality in the ispi-lateral lobe (hazard ratio, 10.059; P =.006) were identified as independent risk factors of recurrence.

CONCLUSION:

For unilateral TNM T1 and T2 PTC patients with lateral lymph node metastasis, there was no significant difference in the effect of TT and LT for RFS in the absence of other risk factors during the follow-up period. Patient age ≥55 years with multifocality in the unilateral lobe might be independent risk factors for prognosis.

• Authors: Zhihong Wang, Jingzhe Xiang, Zhiqiang Gui, Yuan Qin, Wei Sun, Jiapeng Huang, Liang He, Wenwu Dong, Dalin Zhang, Ting Zhang, Liang Shao, Chengzhou Lv, Ping Zhang, Hao Zhang
• Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (Endocr Pract) Vol. 26 Issue 10 Pg. 1085-1092 (Oct 2020) ISSN: 1530-891X [Print] United States
• PMID: 33471710 (Publication Type: Journal Article)
• Copyright: © 2020 American Association of Clinical Endocrinologists. Published by Elsevier, Inc. All rights reserved.

Chemical References

• Iodine Radioisotopes

Topics

• Carcinoma, Papillary (surgery)
• Follow-Up Studies
• Humans
• Iodine Radioisotopes
• Lymph Nodes
• Lymphatic Metastasis
• Neoplasm Recurrence, Local
• Retrospective Studies
• Thyroid Cancer, Papillary (surgery)
• Thyroid Neoplasms (surgery)
• Thyroidectomy