Self-assembled organic nanomedicine enables ultrastable photo-to-heat converting theranostics in the second near-infrared biowindow.

Abstract

Development of organic theranostic agents that are active in the second near-infrared (NIR-II, 1000-1700 nm) biowindow is of vital significance for treating deep-seated tumors. However, studies on organic NIR-II absorbing agents for photo-to-heat energy-converting theranostics are still rare simply because of tedious synthetic routes to construct extended π systems in the NIR-II region. Herein, we design a convenient strategy to engineer highly stable organic NIR-II absorbing theranostic nanoparticles (Nano-BFF) for effective phototheranostic applications via co-assembling first NIR (NIR-I, 650-1000 nm) absorbing boron difluoride formazanate (BFF) dye with a biocompatible polymer, endowing the Nano-BFF with remarkable theranostic performance in the NIR-II region. In vitro and in vivo investigations validate that Nano-BFF can serve as an efficient theranostic agent to achieve photoacoustic imaging guided deep-tissue photonic hyperthermia in the NIR-II biowindow, achieving dramatic inhibition toward orthotopic hepatocellular carcinoma. This work thus provides an insight into the exploration of versatile organic NIR-II absorbing nanoparticles toward future practical applications.

• Authors: Huijing Xiang, Lingzhi Zhao, Luodan Yu, Hongzhong Chen, Chenyang Wei, Yu Chen, Yanli Zhao
• Journal: Nature communications (Nat Commun) Vol. 12 Issue 1 Pg. 218 (01 11 2021) ISSN: 2041-1723 [Electronic] England
• PMID: 33431882 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Formazans
• Organic Chemicals

Topics

• Animals
• Cell Line, Tumor
• Formazans (administration & dosage, pharmacokinetics)
• Hot Temperature
• Infrared Rays
• Light
• Mice, Inbred C57BL
• Neoplasms (pathology, therapy)
• Organic Chemicals (chemistry)
• Photoacoustic Techniques
• Photothermal Therapy
• Theranostic Nanomedicine