Recommendations for the diagnosis and management of transthyretin amyloidosis with gastrointestinal manifestations.

Abstract

Transthyretin amyloid (ATTR) amyloidosis is an adult-onset, rare systemic disorder characterized by the accumulation of misfolded fibrils in the body, including the peripheral nerves, the heart and the gastrointestinal tract. Gastrointestinal manifestations are common in hereditary (ATTRv) amyloidosis and are present even before the onset of the polyneuropathy in some cases. Delays in diagnosis of ATTRv amyloidosis with gastrointestinal manifestations commonly occur because of fragmented knowledge among gastroenterologists and general practitioners, as well as a shortage of centers of excellence and specialists dedicated to disease management. Although the disease is becoming well-recognized in the societies of Neurology and Cardiology, it is still unknown for most gastroenterologists. This review presents the recommendations for ATTRv amyloidosis with gastrointestinal manifestations elaborated by a working group of European gastroenterologists and neurologists, and aims to provide digestive health specialists with an overview of crucial aspects of ATTRv amyloidosis diagnosis to help facilitate rapid and accurate identification of the disease by focusing on disease presentation, misdiagnosis and management of gastrointestinal symptoms.

• Authors: Radislav Nakov, Ole B Suhr, Gianluca Ianiro, Juozas Kupcinskas, Jonathon P Segal, Dan L Dumitrascu, Henriette Heinrich, Ivana Mikolasevic, Milica Stojkovic-Lalosevic, Ivan Barbov, Stayko Sarafov, Ivailo Tournev, Ventsislav Nakov, Jonas Wixner
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 33 Issue 5 Pg. 613-622 (05 01 2021) ISSN: 1473-5687 [Electronic] England
• PMID: 33394808 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Prealbumin

Topics

• Adult
• Amyloid Neuropathies, Familial (diagnosis, genetics, therapy)
• Gastrointestinal Diseases (diagnosis, etiology, therapy)
• Humans
• Prealbumin