Selective transmembrane transport of Aβ protein regulated by tryptophan enantiomers.

Abstract

Tryptophan enantiomers (d/l-Trp) were introduced into artificial nanochannels to regulate the chiral selective transport of Aβ proteins. The l-Trp channel performs effectively selectivity for the transport of Aβ protein, which would provide a new perspective for the pathological studies of Alzheimer's disease.

• Authors: Fei Zhu , Wenqian Wang , Fan Zhang , Manivannan Kalavathi Dhinakaran , Yingqian Wang , Rui Wang , Jing Cheng , Maria Eugenia Toimil-Molares , Christina Trautmann , Haibing Li
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 57 Issue 2 Pg. 215-218 (Jan 07 2021) ISSN: 1364-548X [Electronic] England
• PMID: 33300917 (Publication Type: Journal Article)

Chemical References

• Amyloid beta-Peptides
• Tryptophan

Topics

• Amyloid beta-Peptides (chemistry, metabolism)
• Biological Transport
• Circular Dichroism
• Microscopy, Confocal
• Microscopy, Electron, Transmission
• Stereoisomerism
• Tryptophan (chemistry, metabolism)