Hydrogel eye drops as a non-invasive drug carrier for topical enhanced Adalimumab permeation and highly efficient uveitis treatment.

Abstract

Uveitis is one of the most popular blind-causing eye diseases worldwide. Adalimumab (ADA) is used for the uveitis treatment through systemic or intravitreal injection at the expense of systemic side effects and increased medical risks. Although eye drops, a non-invasive topical treatment, could be a potential strategy to reduce side effects, it remains challenging to apply due to limited bioavailability mainly linked to poor retention time and permeation capacity for eye biological barriers. Here, we reported hydrogel eye drops composed of low-deacetylated chitosan and β-glycerophosphate as an ADA carrier and tested its toxicity, tolerability, intraocular permeability, and efficacy of non-invasive treatment for uveitis. It's found the ADA-loaded hydrogel eye drops were more efficient than free ADA both in permeation rate and clinical efficacy for uveitis, Overall, this study provides a friendly non-invasive strategy to improve drug permeation rate and uveitis treatment efficacy, which may be valuable to clinically ophthalmic medication.

• Authors: Zhongxing Chen, Mei Yang, Qing Wang, Jieyi Bai, Colm McAlinden, Eirini Skiadaresi, Jun Zhang, Luting Pan, Chenyang Mei, Zhenhai Zeng, Jinjin Yu, Yifan Feng, Zhengxuan Jiang, Wenjin Xu, Hang Xu, Xiuhong Ye, Huanhuan He, Qinmei Wang, Junjie Deng, Jinhai Huang
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 253 Pg. 117216 (Feb 01 2021) ISSN: 1879-1344 [Electronic] England
• PMID: 33278980 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Biocompatible Materials
• Drug Carriers
• Glycerophosphates
• Hydrogels
• Ophthalmic Solutions
• Chitosan
• Adalimumab
• beta-glycerophosphoric acid

Topics

• Adalimumab (administration & dosage, pharmacokinetics)
• Administration, Ophthalmic
• Animals
• Anti-Inflammatory Agents (administration & dosage, pharmacokinetics)
• Biocompatible Materials (administration & dosage, chemistry)
• Biological Availability
• Chitosan
• Drug Carriers (administration & dosage, chemistry)
• Drug Liberation
• Female
• Glycerophosphates
• Hydrogels (administration & dosage, chemistry)
• Male
• Ophthalmic Solutions (administration & dosage, chemistry)
• Permeability (drug effects)
• Rabbits
• Rats
• Rats, Sprague-Dawley
• Treatment Outcome
• Uveitis (drug therapy)