Novel insights toward human stroke-related epigenetics: circular RNA and its impact in poststroke processes.

Abstract

Aim: Circular RNAs (circRNAs) are dysregulated in complex diseases, so we investigated their global expression profile in stroke. Material & methods: Public RNA-Seq data of human ischemic stroke lesion tissues and controls were used to perform the global expression analysis. Target RNA binding proteins and microRNAs were predicted in silico. Functional enrichment analysis was performed to infer the circRNAs' potential roles. Results: We found that circRNAs are potentially involved in synaptic components and transmission, inflammation and ataxia. An integrative analysis revealed that hsa_circ_0078299 and FXN may be major players in the molecular stroke-context. Conclusion: Our results suggest a broad involvement of circRNAs in some stroke-related processes, indicating their potential as therapeutic targets to allow neuroprotection and brain recovery.

• Authors: Pablo W Silva, Samara M M Shimon, Leonardo M de Brito, Laís Reis-das-Mercês, Leandro Magalhães, Gilderlanio Araújo, Ândrea Ribeiro-Dos-Santos, Amanda F Vidal
• Journal: Epigenomics (Epigenomics) Vol. 12 Issue 22 Pg. 1957-1968 (11 2020) ISSN: 1750-192X [Electronic] England
• PMID: 33242258 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• MicroRNAs
• RNA, Circular
• RNA-Binding Proteins

Topics

• Epigenesis, Genetic
• Gene Expression Regulation
• Humans
• Ischemic Stroke (genetics, metabolism)
• MicroRNAs (metabolism)
• RNA, Circular (metabolism, physiology)
• RNA-Binding Proteins (genetics)
• RNA-Seq