Clinical Observation and Prognostic Analysis of Patients With Klebsiella pneumoniae Bloodstream Infection.

Abstract

Background and purpose:

The clinical prognosis of Klebsiella pneumoniae(K. pneumoniae) bloodstream infection is poor, and the prevalence of drug-resistant bacteria makes clinical anti-infective treatment more challenging. This retrospective study evaluated the epidemiological characteristics of patients with K. pneumoniae, the risk factors for drug-resistant bacterial infection and death, and analyzed treatment options.

Methods:

Clinical data of 297 patients diagnosed with K. pneumoniae bacteremia between June 2014 and June 2019 were collected.

Results:

Intensive care unit hospitalization history, operation history, recent antibiotic use history, mechanical ventilation, and number of days hospitalized before bloodstream infection were found to be independent risk factors for drug-resistant bacterial infection. The risk of death for carbapenem-resistant K. pneumoniae infection was 2.942 times higher than that for carbapenem-sensitive K. pneumoniae infection. For extensively drug-resistant K. pneumoniae bacteremia patients, the mortality rate of combined anti-infective therapy was lower.

Conclusions:

Clinicians should pay attention to patients with high-risk drug-resistant bacteria infection and administer timely anti-infection treatment. The findings of this study may provide some suggestions for early identification and standardized treatment of patients with K. pneumoniae bacteremia.

• Authors: Shuguang Zhang, Ziyue Yang, Limin Sun, Zhenhua Wang, Liutao Sun, Jinli Xu, Li Zeng, Tongwen Sun
• Journal: Frontiers in cellular and infection microbiology (Front Cell Infect Microbiol) Vol. 10 Pg. 577244 ( 2020) ISSN: 2235-2988 [Electronic] Switzerland
• PMID: 33240822 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Zhang, Yang, Sun, Wang, Sun, Xu, Zeng and Sun.

Chemical References

• Anti-Bacterial Agents

Topics

• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Bacteremia (drug therapy, epidemiology)
• Drug Resistance, Bacterial
• Humans
• Klebsiella Infections (drug therapy, epidemiology)
• Klebsiella pneumoniae
• Prognosis
• Retrospective Studies
• Risk Factors