Synthesis and antiviral activity of lycorine derivatives.

Abstract

There are no effective antiviral drugs to treat hand, foot, and mouth disease. In this study, a series of lycorine derivatives were synthesized and evaluated against enterovirus 71 and coxsackievirus A16 in vitro. Derivatives 7c-m with the phenoxyacyl group at the C-1 position showed higher efficacy and lower toxicity than lycorine. In addition, derivative 7e enhanced the survival rate to 40% in the mouse model of the lethal EV71 infection.

• Authors: Ya-Jun Yang, Jiang-Ning Liu, Xian-Dao Pan
• Journal: Journal of Asian natural products research (J Asian Nat Prod Res) Vol. 22 Issue 12 Pg. 1188-1196 (Dec 2020) ISSN: 1477-2213 [Electronic] England
• PMID: 33176482 (Publication Type: Journal Article)

Chemical References

• Amaryllidaceae Alkaloids
• Antiviral Agents
• Phenanthridines
• lycorine

Topics

• Amaryllidaceae Alkaloids
• Animals
• Antiviral Agents (pharmacology)
• Enterovirus
• Enterovirus A, Human
• Hand, Foot and Mouth Disease
• Mice
• Molecular Structure
• Phenanthridines