RETRACTED: Long noncoding RNA LINC00671 exacerbates osteoarthritis by promoting ONECUT2-mediated Smurf2 expression and extracellular matrix degradation.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Authors and Editor-in-Chief. The corresponding author contacted the journal and stated: “…we have obtained different results from this paper (onecut2 targeted regulation of Smurf2 / GSK-3 β part), and repeated experiments cannot fully verify this result”. The authors requested retraction of the article. Concern was also raised about the integrity of an image in Figure 1H, which appears to also be found in another publication, as detailed here: https://pubpeer.com/publications/FBECF0BCB952DCC563AA5C4D760B32 and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. The journal requested the corresponding author comment on these concerns and provide the raw data. The authors were unable to satisfactorily fulfill this request. The Editor-in-Chief assessed the case and decided to retract the article.

• Authors: Chengwei Chen, Yaozeng Xu
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 90 Pg. 106846 (01 2021) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 33168412 (Publication Type: Journal Article, Retracted Publication)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Homeodomain Proteins
• ONECUT2 protein, human
• ONECUT2 protein, mouse
• RNA, Long Noncoding
• Transcription Factors
• SMURF2 protein, human
• Smurf2 protein, mouse
• Ubiquitin-Protein Ligases
• GSK3B protein, human
• Glycogen Synthase Kinase 3 beta
• Gsk3b protein, mouse

Topics

• Adult
• Aged
• Animals
• Apoptosis
• Case-Control Studies
• Cell Proliferation
• Cells, Cultured
• Chondrocytes (enzymology, pathology)
• Databases, Genetic
• Disease Models, Animal
• Disease Progression
• Extracellular Matrix (enzymology, pathology)
• Female
• Gene Expression Regulation
• Glycogen Synthase Kinase 3 beta (genetics, metabolism)
• Homeodomain Proteins (genetics, metabolism)
• Humans
• Knee Joint (enzymology, pathology)
• Male
• Mice, Inbred C57BL
• Middle Aged
• Osteoarthritis, Knee (enzymology, genetics, pathology)
• RNA, Long Noncoding (genetics, metabolism)
• Signal Transduction
• Transcription Factors (genetics, metabolism)
• Ubiquitin-Protein Ligases (genetics, metabolism)
• Ubiquitination
• Mice