Abstract | PURPOSE: METHODS: A literature search for articles on the angiopoietin/Tie pathway and molecules targeting this pathway that have reached Phase 2 or 3 trials was undertaken on PubMed, Association for Research in Vision and Ophthalmology meeting abstracts (2014-2019), and ClinicalTrials.gov databases. Additional information on identified pipeline drugs was obtained from publicly available information on company websites. RESULTS: The PubMed and Association for Research in Vision and Ophthalmology meeting abstract search yielded 462 results, of which 251 publications not relevant to the scope of the review were excluded. Of the 141 trials related to the angiopoietin/Tie pathway on ClinicalTrials.gov, seven trials focusing on diseases covered in this review were selected. Vision/anatomic outcomes from key clinical trials on molecules targeting the angiopoietin/Tie pathway in patients with retinal vascular diseases are discussed. CONCLUSION:
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Authors | Jeffrey S Heier, Rishi P Singh, Charles C Wykoff, Karl G Csaky, Timothy Y Y Lai, Anat Loewenstein, Patricio G Schlottmann, Liliana P Paris, Peter D Westenskow, Carlos Quezada-Ruiz |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 41
Issue 1
Pg. 1-19
(01 01 2021)
ISSN: 1539-2864 [Electronic] United States |
PMID | 33136975
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc. |
Chemical References |
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Topics |
- Angiopoietins
(therapeutic use)
- Humans
- Retinal Diseases
(diagnosis, drug therapy)
- Retinal Vessels
(pathology)
- Signal Transduction
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