Abstract | AIM: METHODS: RESULTS: In total, 188 patients were included (83.5% of them aged >75 years). Glutamate dehydrogenase positivity was independently associated with in-hospital mortality (adjusted odds ratio 2.19, 95% confidence interval 1.14-4.21) and hospital stay length (regression coefficient 16.0, 95% confidence interval 5.15-26.9). Clostridioides difficile toxin positivity was independently associated with hospital stay duration (regression coefficient 14.5, 95% confidence interval 0.04-29.1), unlike in-hospital mortality. CONCLUSIONS:
Glutamate dehydrogenase was closely related to in-hospital mortality and prolonged hospitalization compared with Clostridioides difficile toxin. Clinicians should not neglect glutamate dehydrogenase-positive patients, even when they are Clostridioides difficile toxin-negative, and consider them as having poor prognostic potential. Geriatr Gerontol Int 2020; 20: 1138-1144.
|
Authors | Yohsuke Nagayoshi, Kazuko Yamamoto, Shuntaro Sato, Naofumi Suyama, Takuya Izumikawa, Kinichi Izumikawa, Taiga Miyazaki, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae |
Journal | Geriatrics & gerontology international
(Geriatr Gerontol Int)
Vol. 20
Issue 12
Pg. 1138-1144
(Dec 2020)
ISSN: 1447-0594 [Electronic] Japan |
PMID | 33098238
(Publication Type: Journal Article)
|
Copyright | © 2020 Japan Geriatrics Society. |
Chemical References |
- Bacterial Proteins
- Bacterial Toxins
- Glutamate Dehydrogenase
|
Topics |
- Bacterial Proteins
- Bacterial Toxins
- Clostridioides
- Clostridioides difficile
- Feces
- Glutamate Dehydrogenase
- Humans
- Retrospective Studies
|