[Effects of recombinant human interferon-alpha A/D on the growth of experimental tumors in mice].

Abstract

The effects of recombinant human interferon-alpha A/D (rIFN-alpha A/D, a subtype of recombinant human leukocyte interferon with biological activities against murine tumor cells) on the growth of murine tumors were studied. rIFN-alpha A/D significantly inhibited the growth of mouse M5076 reticulum cell sarcoma, MOPC-104E myeloma, colon carcinoma 26 and Meth A fibrosarcoma by dose-dependent fashion. rIFN-alpha A/D also inhibited the metastases and growth of Lewis lung carcinoma and showed a synergistic effect with combination of cyclophosphamide. The antitumor activity of rIFN-alpha A/D was observed by intra-muscular, intravenous, subcutaneous, intraperitoneal injections or by the injection at the site of the tumors.

• Authors: K Ootsu, Y Kozai, T Houkan, K Gotoh, E Matsutani
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 14 Issue 8 Pg. 2502-8 (Aug 1987) ISSN: 0385-0684 [Print] Japan
• PMID: 3304169 (Publication Type: English Abstract, Journal Article)

Chemical References

• Interferon Type I
• Recombinant Proteins

Topics

• Animals
• Female
• Fibrosarcoma (therapy)
• Interferon Type I (therapeutic use)
• Lymphoma, Large B-Cell, Diffuse (therapy)
• Mice
• Mice, Inbred Strains
• Neoplasms, Experimental (pathology, therapy)
• Recombinant Proteins (therapeutic use)