Abstract | BACKGROUND:
Disaccharides such as lactose and sucrose are sugars commonly found in human diet. They are broken down by mucosal disaccharidases in the duodenum. Previous small studies found no associations between gastrointestinal (GI) symptoms and combined low disaccharidase activity. We aim to explore the associations of low activity of disaccharidase and combinations of low activity of different disaccharidases with general GI symptom presentations in a large cohort of pediatric patients. METHODS: RESULTS: Of the 347 subjects, we found an association between low lactase activity and abdominal pain (OR = 1.78; 95% CI = 1.07-2.97; p < 0.05). Subjects with a lactase/ sucrase ratio < 0.2 were found to be associated with abdominal pain (OR = 2.25; 95% CI = 1.25-4.04; p < 0.05), Subjects with low pandisaccharidase may be correlated with abdominal pain and have a unique frequency of GI symptoms due to low frequency of diarrhea and weight loss, but they were not statistically significant. CONCLUSIONS: Low activities of certain disaccharidase combinations may be associated with GI symptoms in subjects; a prospective study may be needed to investigate further.
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Authors | Paul Wasuwanich, Hassan Choudry, Thammasin Ingviya, Ann O Scheimann, Karla J AuYeung, Christine Karwowski, Susan Billet, Buford L Nichols, Wikrom Karnsakul |
Journal | BMC gastroenterology
(BMC Gastroenterol)
Vol. 20
Issue 1
Pg. 331
(Oct 09 2020)
ISSN: 1471-230X [Electronic] England |
PMID | 33036568
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Child
- Disaccharidases
- Duodenum
- Humans
- Lactase
- Prospective Studies
- Retrospective Studies
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