The role of microenvironment in tumor angiogenesis.

Abstract

Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment-composed of tumor cells, surrounding cells, and secreted cytokines-provides a conducive environment for the growth and survival of tumors. Different components of the tumor microenvironment can regulate tumor development. In this review, we have discussed the regulatory role of the microenvironment in tumor angiogenesis. High expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic drugs. A combination of anti-angiogenic drugs and antitumor inflammatory drugs or hypoxia inhibitors might improve the therapeutic outcome.

• Authors: Xianjie Jiang, Jie Wang, Xiangying Deng, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Ke Cao, Hao Deng, Yi He, Qianjin Liao, Bo Xiang, Ming Zhou, Can Guo, Zhaoyang Zeng, Guiyuan Li, Xiaoling Li, Wei Xiong
• Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 39 Issue 1 Pg. 204 (Sep 30 2020) ISSN: 1756-9966 [Electronic] England
• PMID: 32993787 (Publication Type: Journal Article, Review)

Chemical References

• Neoplasm Proteins

Topics

• Cell Proliferation (genetics)
• Cell Survival (genetics)
• Gene Expression Regulation, Neoplastic (genetics)
• Humans
• Neoplasm Invasiveness (genetics, pathology)
• Neoplasm Proteins (genetics)
• Neoplasms (genetics, pathology)
• Neovascularization, Pathologic (genetics, pathology)
• Tumor Microenvironment (genetics)