Abstract | PURPOSE: METHODS: Analysis included all patients admitted between 2009 and 2017 with PC from CRC who were treated with curative intent by CRS- Mitomycin C- HIPEC. Patients were assessed pre- and intra-operatively by the PC index (PCI) and by a completeness of cytoreduction (CC) score with calculation of Kaplan-Meier survival curves and multivariate analysis of prognostic factors. Discrimination was made for NLR >3.5, PLR >168.8 and LMR >4.4. RESULTS: We identified 98 CRC patients undergoing 105 CRS- HIPEC procedures. There were no associations detected between NLR/PLR/LMR and the rates of incomplete or abandoned CRS cases. Overall survival (OS) after CRS- HIPEC was worse with high versus low NLR (19.9 mths vs. 45.7 mths, respectively; P = 0.009) and also with low versus high LMR (27.1 mths vs. 53.2 mths, respectively; P = 0.01). On multivariate analysis, a low LMR (P = 0.008), the preoperative CT PCI value (P = 0.004), poor tumor differentiation (P = 0.023) and the preoperative CEA level (P < 0.001) were all independent variables associated with a worse OS after surgery. CONCLUSIONS: The baseline LMR value may have potential value as a selection tool for CRS- HIPEC in patients with CRC-related PC.
|
Authors | Yaniv Zager, Aviad Hoffman, Yael Dreznik, Harel Jacoby, Mordehay Cordoba, Nir Horesh, Avinoam Nevler, Mordechai Gutman, Yaniv Berger |
Journal | Surgical oncology
(Surg Oncol)
Vol. 35
Pg. 321-327
(Dec 2020)
ISSN: 1879-3320 [Electronic] Netherlands |
PMID | 32977104
(Publication Type: Comparative Study, Journal Article)
|
Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
Topics |
- Aged
- Blood Platelets
- Colorectal Neoplasms
(blood, drug therapy, pathology, surgery)
- Combined Modality Therapy
- Cytoreduction Surgical Procedures
- Female
- Humans
- Hyperthermic Intraperitoneal Chemotherapy
- Israel
- Lymphocytes
- Male
- Middle Aged
- Monocytes
- Neutrophils
- Peritoneal Neoplasms
(secondary)
- Prognosis
- Treatment Outcome
|