Predisposition to Hyperthyroidism May Be Influenced by Functional TNF-α, IL-1, IL-6, and IL-10 Polymorphisms: A Meta-Analysis.

Abstract

BACKGROUND:

Predisposition to hyperthyroidism may be influenced by functional gene polymorphisms in tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-4 (IL-4), interleukin-6 (IL-6), and interleukin-10 (IL-10). However, the results of the studies published so far remain discrepant, so we conducted a meta-analysis to more robustly investigate relationships between TNF-α/IL-1/IL-4/IL-6/IL-10 polymorphisms and predisposition to hyperthyroidism.

METHODS:

A comprehensive literature retrieval from PubMed, Embase, Web of Science, WanFang, VIP, and CNKI was endorsed by the authors, and 38 studies were found to be eligible for pooled meta-analyses.

RESULTS:

We found that genotypic frequencies of TNF-α -308 G/A, IL-1A -889 C/T, IL-6 -174 G/C, IL-6 -572 G/C, IL-10 -819 C/T, and IL-10 -1082 A/G polymorphisms among cases were significantly different from those among controls. Moreover, we also found that genotypic frequencies of TNF-α -308 G/A and IL-6 -174 G/C polymorphisms among cases of Caucasian origin were significantly different from those among Caucasian controls, and genotypic frequencies of IL-1A -889 C/T, IL-1B -511 C/T, IL-6 -174 G/C, IL-6 -572 G/C, and IL-10 -1,082 A/G polymorphisms among cases of Asian origin were also significantly different from those among Asian controls.

CONCLUSIONS:

This meta-analysis suggests that TNF-α -308 G/A, IL-1A -889 C/T, IL-1B -511 C/T, IL-6 -174 G/C, IL-6 -572 G/C, IL-10 -819 C/T, and IL-10 -1,082 A/G polymorphisms may influence predisposition to hyperthyroidism in certain ethnic groups.

• Authors: Hong Ma, Ting Tan, Jie Wu, Juan Chen, Xiaohong Zhang
• Journal: International archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 181 Issue 12 Pg. 956-965 ( 2020) ISSN: 1423-0097 [Electronic] Switzerland
• PMID: 32942281 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: © 2020 S. Karger AG, Basel.

Chemical References

• Interleukin-1
• Interleukin-6
• Tumor Necrosis Factor-alpha
• Interleukin-10

Topics

• Ethnicity
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Hyperthyroidism (genetics, immunology)
• Interleukin-1 (genetics)
• Interleukin-10 (genetics)
• Interleukin-6 (genetics)
• Polymorphism, Single Nucleotide
• Tumor Necrosis Factor-alpha (genetics)