Melflufen for relapsed and refractory multiple myeloma.

Abstract

INTRODUCTION:

The overall survival of patients with multiple myeloma has improved with the advent of novel agents; however, multiple myeloma remains incurable. Combinations of standard-of-care agents such as immunomodulators, proteasome inhibitors, and anti-CD38 monoclonal antibodies are increasingly used in earlier lines of therapy. Patients with disease that is refractory to multiple novel agents represent a population with high unmet medical need and for whom therapies with new mechanisms of action could be beneficial. Melphalan flufenamide (melflufen) has demonstrated encouraging activity in patients with relapsed and refractory multiple myeloma.

AREAS COVERED:

This review provides an overview of the mechanism of action of melflufen, a first-in-class peptide-drug conjugate that targets aminopeptidases and rapidly delivers alkylating agents into tumor cells. It reviews key Phase I and II clinical trial data for melflufen in combination with dexamethasone as well as in triplet combinations with daratumumab or bortezomib. The safety profile of melflufen, which is characterized primarily by clinically manageable hematologic adverse events, is described.

EXPERT OPINION:

Melflufen has potential to fill a gap in the myeloma treatment landscape by providing a new mechanism of action with clinically meaningful efficacy and a favorable safety profile in patients refractory to multiple novel agents.

• Authors: Albert Oriol, Alessandra Larocca, Xavier Leleu, Roman Hajek, Hani Hassoun, Paula Rodríguez-Otero, Agne Paner, Fredrik H Schjesvold, Joachim Gullbo, Paul G Richardson
• Journal: Expert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 29 Issue 10 Pg. 1069-1078 (Oct 2020) ISSN: 1744-7658 [Electronic] England
• PMID: 32924646 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents, Alkylating
• melflufen
• Phenylalanine
• Melphalan

Topics

• Antineoplastic Agents, Alkylating (administration & dosage, adverse effects, pharmacology)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects, pharmacology)
• Humans
• Melphalan (administration & dosage, adverse effects, analogs & derivatives, pharmacology)
• Multiple Myeloma (drug therapy, pathology)
• Phenylalanine (administration & dosage, adverse effects, analogs & derivatives, pharmacology)
• Recurrence
• Survival Rate