Reproductive outcomes after floxuridine-based regimens for gestational trophoblastic neoplasia: A retrospective cohort study in a national referral center in China.

Abstract

OBJECTIVE:

To analyze the reproductive outcomes of gestational trophoblastic neoplasia (GTN) patients who were cured only by floxuridine-based regimens.

METHODS:

This was a retrospective analysis of 464 patients who were treated with only floxuridine-based regimens at Peking Union Medical College Hospital between January 2002 and December 2013 and retained their reproductive ability. Their reproductive outcomes were analyzed. The factors affecting pregnancy intention were identified by logistic regression.

RESULTS:

Of the 464 patients (average age, 28.0 ± 5.7 years; median follow-up = 85 months), the livebirth rate was 72.2%, while the rates of spontaneous abortion, induced abortion and ectopic pregnancy were 9.2% (n = 41), 8.7% (n = 39) and 1.8% (n = 8), respectively. The GTN recurrence rate was 2.1%. The time from chemotherapy completion to first conception in the induced abortion group was significantly shorter than those in spontaneous abortion, full-term/premature, and ectopic pregnancy groups (P ≤ 0.001, <0.001, =0.015, respectively). The logistic analysis showed that the age at onset of GTN (OR = 0.899, 95% CI 0.851-0.951, P < 0.001), parity at onset of GTN (parity = 1, OR = 0.123, 95% CI 0.068-0.225, P < 0.001; parity = 2-3, OR = 0.058, 95% CI 0.014-0.232, P < 0.001) and interval from the index pregnancy to chemotherapy were independent factors affecting pregnancy intention. Among the 36 pregnancies occurring within 12 months postchemotherapy, only one choriocarcinoma occurred, and 20 culminated in induced abortions (55.6%).

CONCLUSIONS:

After floxuridine-based chemotherapy, the pregnancy rate of GTN patients after fertility-preserving treatment is comparable to that of the normal population. Pregnancy losses within one year after chemotherapy completion are mainly caused by induced abortion.

• Authors: Fang Jiang, Kun Yang, Xi-Run Wan, Yang Xiang, Feng-Zhi Feng, Tong Ren, Jun-Jun Yang, Jun Zhao
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 159 Issue 2 Pg. 464-469 (11 2020) ISSN: 1095-6859 [Electronic] United States
• PMID: 32917411 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Antimetabolites, Antineoplastic
• Floxuridine

Topics

• Adult
• Antimetabolites, Antineoplastic (administration & dosage)
• China (epidemiology)
• Female
• Fertility Preservation
• Floxuridine (administration & dosage)
• Gestational Trophoblastic Disease (drug therapy, epidemiology)
• Humans
• Intention
• Live Birth (epidemiology)
• Pregnancy
• Retrospective Studies
• Time-to-Pregnancy
• Young Adult