Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis.

Abstract

BACKGROUND:

The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease.

METHODS:

Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/m2, 2 days), ifosfamide (2 g/m2, 5 days), and etoposide (100 mg/m2, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen.

RESULTS:

Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period.

CONCLUSION:

This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered.

• Authors: Shiro Saito, Hisaki Aiba, Satoshi Yamada, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Takanobu Otsuka, Hideki Murakami
• Journal: BMC cancer (BMC Cancer) Vol. 20 Issue 1 Pg. 868 (Sep 09 2020) ISSN: 1471-2407 [Electronic] England
• PMID: 32907549 (Publication Type: Journal Article)

Chemical References

• Etoposide
• Doxorubicin
• pirarubicin
• Ifosfamide

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Disease-Free Survival
• Doxorubicin (administration & dosage, adverse effects, analogs & derivatives)
• Drug-Related Side Effects and Adverse Reactions (classification, pathology)
• Etoposide (administration & dosage, adverse effects)
• Female
• Humans
• Ifosfamide (administration & dosage, adverse effects)
• Leukopenia (chemically induced, pathology)
• Male
• Middle Aged
• Sarcoma (drug therapy, pathology)
• Thrombocytopenia (chemically induced, pathology)