Cancer Cell Membrane Camouflaged Semi-Yolk@Spiky-Shell Nanomotor for Enhanced Cell Adhesion and Synergistic Therapy.

Abstract

Cell adhesion of nanosystems is significant for efficient cellular uptake and drug delivery in cancer therapy. Herein, a near-infrared (NIR) light-driven biomimetic nanomotor is reported to achieve the improved cell adhesion and cellular uptake for synergistic photothermal and chemotherapy of breast cancer. The nanomotor is composed of carbon@silica (C@SiO2 ) with semi-yolk@spiky-shell structure, loaded with the anticancer drug doxorubicin (DOX) and camouflaged with MCF-7 breast cancer cell membrane (i.e., mC@SiO2 @DOX). Such biomimetic mC@SiO2 @DOX nanomotors display efficient self-thermophoretic propulsion due to a thermal gradient generated by asymmetrically spatial distribution. Moreover, the MCF-7 cancer cell membrane coating can remarkably reduce the bioadhesion of nanomotors in biological medium and exhibit highly specific self-recognition of the source cell line. The combination of effective propulsion and homologous targeting dramatically improves cell adhesion and the resultant cellular uptake efficiency in vitro from 26.2% to 67.5%. Therefore, the biomimetic mC@SiO2 @DOX displays excellent synergistic photothermal and chemotherapy with over 91% MCF-7 cell growth inhibition rate. Such smart design of the fuel-free, NIR light-powered biomimetic nanomotor may pave the way for the application of self-propelled nanomotors in biomedicine.

• Authors: Mengyun Zhou, Yi Xing, Xiaoyu Li, Xin Du, Tailin Xu, Xueji Zhang
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 16 Issue 39 Pg. e2003834 (10 2020) ISSN: 1613-6829 [Electronic] Germany
• PMID: 32877017 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 Wiley-VCH GmbH.

Chemical References

• Antineoplastic Agents
• Carbon
• Silicon Dioxide
• Doxorubicin

Topics

• Antineoplastic Agents (therapeutic use)
• Biomimetic Materials (chemistry, therapeutic use)
• Breast Neoplasms (therapy)
• Carbon (chemistry)
• Cell Adhesion
• Cell Membrane
• Doxorubicin (administration & dosage)
• Drug Therapy (instrumentation)
• Female
• Humans
• MCF-7 Cells
• Nanostructures (chemistry)
• Phototherapy (instrumentation)
• Silicon Dioxide (chemistry)