D-Dimer to Fibrinogen Ratio as a Novel Prognostic Marker in Patients After Undergoing Percutaneous Coronary Intervention: A Retrospective Cohort Study.

Abstract	The role of activation of the coagulation and fibrinolysis system in the pathogenesis and prognosis of cardiovascular diseases (CVDs) has drawn wide attention. Recently, the D-dimer to fibrinogen ratio (DFR) is considered as a useful biomarker for the diagnosis and prognosis of ischemic stroke and pulmonary embolism. However, few studies have explored the relationship between DFR and cardiovascular disease. In our study, patients were divided into 2 groups according to DFR value: the lower group (DFR < 0.52, n = 2123) and the higher group (DFR ≥ 0.52, n = 1073). The primary outcome was all-cause mortality (ACM) and cardiac mortality (CM). The average follow-up time was 37.59 ± 22.24 months. We found that there were significant differences between the 2 groups in term of ACM (2.4% vs 6.6%, P < 0.001) and CM (1.5% vs 4.0%, P < 0.001). Kaplan-Meier analyses showed that elevated DFR had higher incidences of ACM (log rank P < 0.001) and CM (log rank P < 0.001). Multivariate Cox regression analyses showed that DFR was an independent predictor of ACM (HR = 1.743, 95%CI: 1.187-2.559 P = 0.005) and CM (HR = 1.695, 95%CI: 1.033-2.781 P = 0.037). This study indicates that DFR is an independent and novel predictor of long-term ACM and CM in post-PCI patients with CAD.
Authors	Yan Bai, Ying-Ying Zheng, Jun-Nan Tang, Xu-Ming Yang, Qian-Qian Guo, Jian-Chao Zhang, Meng-Die Cheng, Feng-Hua Song, Kai Wang, Zeng-Lei Zhang, Zhi-Yu Liu, Li-Zhu Jiang, Lei Fan, Xiao-Ting Yue, Xin-Ya Dai, Ru-Jie Zheng, Jin-Ying Zhang
Journal	Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) 2020 Jan-Dec Vol. 26 Pg. 1076029620948586 ISSN: 1938-2723 [Electronic] United States
PMID	32842770 (Publication Type: Journal Article)
Chemical References	Fibrin Fibrinogen Degradation Products fibrin fragment D Fibrinogen
Topics	Aged Female Fibrin Fibrinogen Degradation Products (metabolism) Fibrinogen (metabolism) Humans Male Middle Aged Percutaneous Coronary Intervention (methods) Prognosis Retrospective Studies Risk Factors

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