Theoretical and Experimental Studies on the Near-Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation.

Abstract

Invited for this month's cover are the collaborating groups of Dr. Masato Kobayashi and Prof. Mikako Ogawa, both from Hokkaido University, Sapporo, Japan. The cover picture shows the photochemical reaction process of the near-infrared (NIR) photoimmunotherapy dye IR700, and subsequent cancer cell death. A computational study predicted that ligand dissociation, which is known to initiate cancer cell death, proceeds by the hydrolysis of the IR700 radical anion, rather than as a direct result of NIR irradiation. This mechanism has also been supported by experimental work. Read the full text of the Communication at 10.1002/cplu.202000338.

• Authors: Masato Kobayashi, Mei Harada, Hideo Takakura, Kanta Ando, Yuto Goto, Takao Tsuneda, Mikako Ogawa, Tetsuya Taketsugu
• Journal: ChemPlusChem (Chempluschem) Vol. 85 Issue 9 Pg. 1953 (09 2020) ISSN: 2192-6506 [Electronic] Germany
• PMID: 32830450 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 Wiley-VCH GmbH.

Chemical References

• Anions
• Indoles
• Organosilicon Compounds
• Photosensitizing Agents
• silicon phthalocyanine

Topics

• Anions
• Humans
• Hydrolysis
• Immunotherapy
• Indoles (chemistry)
• Infrared Rays
• Models, Theoretical
• Organosilicon Compounds (chemistry)
• Photosensitizing Agents (pharmacology)
• Phototherapy