Abstract | BACKGROUND: METHODS: Among 57,075 postmenopausal women in the Cancer Prevention Study-II Nutrition Cohort who were cancer free and reported coffee intake in 1999, we identified 2,980 women diagnosed with invasive breast cancer during follow-up through June 2015. Multivariable-adjusted Cox proportional hazards regression was used to compute hazard ratios (HR) and 95% confidence intervals (CI). RESULTS: Neither total, caffeinated, nor decaffeinated coffee consumption was associated with invasive breast cancer risk; HRs (95% CIs) comparing consumption of ≥2 cups per day with <1 cup per month were 0.99 (0.89-1.11), 0.96 (0.87-1.06), and 1.06 (0.95-1.19), respectively. Similarly, coffee consumption was not associated with risk of hormone receptor-positive (ER+ or PR+) or hormone receptor-negative (ER- and PR-) breast tumors. CONCLUSIONS: These findings do not support an association between coffee consumption and invasive breast cancer risk among postmenopausal women. IMPACT: This large prospective study contributes to the limited evidence on coffee consumption and breast cancer risk, finding no association overall or by tumor receptor subtype.
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Authors | Susan M Gapstur, Mia M Gaudet, Ying Wang, Rebecca A Hodge, Caroline Y Um, Terryl J Hartman, Marjorie L McCullough |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 29
Issue 11
Pg. 2383-2386
(11 2020)
ISSN: 1538-7755 [Electronic] United States |
PMID | 32817071
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Copyright | ©2020 American Association for Cancer Research. |
Chemical References |
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Topics |
- Breast Neoplasms
(etiology, physiopathology)
- Coffee
(adverse effects)
- Female
- Humans
- Incidence
- Middle Aged
- Nutritional Status
- Postmenopause
- Risk Factors
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