PINK1: The guard of mitochondria.

Abstract

PTEN-induced putative kinase 1 (PINK1) performs many important functions in cells and has been highlighted for its role in early-onset Parkinson's disease. In recent years, an increasing number of studies have revealed the involvement of PINK1 in regulation of a variety of cell physiological and pathophysiological processes, of which regulation of mitochondrial function remains the most prominent. As the "energy factory" of cells, mitochondria provide energy support for various cellular activities. Changes in mitochondrial function often have a fundamental and global impact on cellular activities. Moreover, mitochondrial dysfunction has been implicated in many diseases, especially those related to aging. Thus, a comprehensive study of PINK1 will help us better understand the various cell physiological and pathophysiological processes in which PINK1 is involved, including a variety of mitochondria-related diseases such as Parkinson's disease. This article will review the structural characteristics and expression regulation of PINK1, as well as its unique role in mitochondrial quality control (MQC) systems.

• Authors: Nan Wang, Peining Zhu, Renxuan Huang, Chong Wang, Liankun Sun, Beiwu Lan, Yichun He, Hongyang Zhao, Yufei Gao
• Journal: Life sciences (Life Sci) Vol. 259 Pg. 118247 (Oct 15 2020) ISSN: 1879-0631 [Electronic] Netherlands
• PMID: 32805222 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Ubiquitin-Protein Ligases
• Protein Kinases
• PTEN-induced putative kinase

Topics

• Age Factors
• Animals
• Autophagy (physiology)
• Humans
• Mitochondria (genetics, metabolism)
• Mitophagy (physiology)
• Parkinson Disease (enzymology, genetics)
• Protein Kinases (genetics, metabolism)
• Ubiquitin-Protein Ligases (metabolism)