Abstract | OBJECTIVE: Stress is a known trigger for seizures in patients with epilepsy (PWE). However, the association between stress and seizures has not been thoroughly investigated. In December 2019, an outbreak of coronavirus disease (COVID-19) occurred in Wuhan, Hubei province, China, causing tremendous collateral stress. This study was designed to evaluate the influence of the COVID-19 outbreak on seizures in PWE in the most severely affected area, Wuhan, and its surrounding cities. METHODS: In this single-center, cross-sectional study, PWE were surveyed via online questionnaires between February 23 and March 5, 2020. Collected data included demographic information, epilepsy-related characteristics (seizure type, frequency, antiepileptic drugs [AEDs], and medication management), direct and perceived threat of COVID-19, and changes in seizures during the outbreak. Psychological comorbidities were evaluated by the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7 items, and Insomnia Severity Index (ISI). Multivariate logistic regression was used to identify precipitants for seizure exacerbation. RESULTS: We received 362 completed questionnaires after excluding 12 duplicates (response rate = 63.51%). A total of 31 (8.56%) patients had increased seizures during the outbreak. Exposure history to COVID-19 (P = .001), uncontrolled seizure after AED therapy (P = .020), seizure frequency of two or more times per month before the outbreak (P = .005), change of AED regimen during the outbreak (AED reduction, withdrawal, replacement, skipping altogether; P = .002), and worry about the adverse effect of the outbreak on overall seizure-related issues (severity = moderate to critical; P = .038) were risk factors for increased seizures. SIGNIFICANCE: A minority of PWE experienced seizure exacerbation during the outbreak of COVID-19. Stress, uncontrolled seizures, and inappropriate change in AED regimen were associated with increased seizures. Based on these findings, stress might be an independent precipitant for triggering seizures in some PWE.
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Authors | Shanshan Huang, Chunmei Wu, Yuchao Jia, Guo Li, Zhou Zhu, Kai Lu, Yuyan Yang, Furong Wang, Suiqiang Zhu |
Journal | Epilepsia
(Epilepsia)
Vol. 61
Issue 9
Pg. 1884-1893
(09 2020)
ISSN: 1528-1167 [Electronic] United States |
PMID | 32761900
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 International League Against Epilepsy. |
Topics |
- Adolescent
- Adult
- Aged
- COVID-19
(psychology)
- Child
- Cross-Sectional Studies
- Epilepsy
(psychology)
- Female
- Humans
- Male
- Middle Aged
- SARS-CoV-2
- Seizures
(psychology)
- Stress, Psychological
(psychology)
- Surveys and Questionnaires
- Symptom Flare Up
- Young Adult
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