Abstract | INTRODUCTION: METHODS: In a 'real-life' study, 300 patients with moderate AD were age-stratified and divided into two groups: patients applying GPI emollient and the comparator. We evaluated the effectiveness of AD treatment using: Eczema Area and Severity Index (EASI), Three Item Severity (TIS), Visual Analogue Scale (VAS) and Four-Item Itch Questionnaire. RESULTS: The GPI emollient was superior in reduction AD symptoms in children: VAS (-2.58 ± 0.25), TIS (-2.22 ± 0.22), EASI (-15.27 ± 1.77), and adults: VAS (-2.42 ± 0.19), TIS (-2.22 ± 0.17), EASI (-13.22 ± 1.53), as compared to the other emollient in children: VAS (-0.67 ± 0.19), TIS (0.47 ± 0.19), EASI (-3.71 ± 1.01) and adults: VAS (-0.86 ± 0.09), TIS (0.77 ± 0.09), EASI (-2.95 ± 0.46), p < .001. Similar results were observed in Four Item Itch Questionnaire. CONCLUSION: Both emollients showed good safety and tolerance profile and reduced AD symptoms. The GPI emollient seems to be more slightly effective in reducing AD symptoms as compared to the other commercially available emollient.
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Authors | Monika Marko, Rafał Pawliczak |
Journal | The Journal of dermatological treatment
(J Dermatolog Treat)
Vol. 33
Issue 2
Pg. 999-1010
(Mar 2022)
ISSN: 1471-1753 [Electronic] England |
PMID | 32746664
(Publication Type: Journal Article)
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Chemical References |
- Emollients
- Inositol Phosphates
- Ointments
- glycerylphosphoinositol
- Choline
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Topics |
- Adult
- Child
- Choline
(therapeutic use)
- Dermatitis, Atopic
(diagnosis, drug therapy)
- Eczema
(drug therapy)
- Emollients
(therapeutic use)
- Humans
- Inositol Phosphates
- Ointments
- Severity of Illness Index
- Treatment Outcome
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