The Impact of Hypertension on the Clinicopathological Outcome and Progression of Renal Cell Carcinoma.

Abstract

BACKGROUND/AIM:

Hypertension is a risk factor for occurrence of renal cell carcinoma; however, it remains unclear whether hypertension affects development and prognosis of renal cell carcinoma. This study evaluated the impact of hypertension on the progression of renal cell carcinoma.

PATIENTS AND METHODS:

Renal cell carcinoma patients who were treated from October 2007 to December 2018 at our Institution were retrospectively analyzed.

RESULTS:

Of 462 patients, the number of patients with and without hypertension was 234 (including 227 treated with anti-hypertensive agents) and 228, respectively. The tumor size was significantly smaller in the hypertension group than in the non-hypertension group (median 32 and 45 mm, respectively, p=0.010). The 5-year cancer-specific and metastasis-free survival in the hypertension group were significantly better than those in the non-hypertension group (93.6% and 80.4%, and 84.6% and 73.0%, respectively, p=0.021 and p=0.017). Propensity score matching revealed significantly better metastatic-free survival in the hypertension group than the non-hypertension group (p=0.022).

CONCLUSION:

Renal cell carcinoma patients with hypertension show better prognosis with low metastasis possibility.

• Authors: Tomoyuki Makino, Kouji Izumi, Hiroaki Iwamoto, Suguru Kadomoto, Renato Naito, Hiroshi Yaegashi, Kazuyoshi Shigehara, Yoshifumi Kadono, Atsushi Mizokami
• Journal: Anticancer research (Anticancer Res) Vol. 40 Issue 7 Pg. 4087-4093 (Jul 2020) ISSN: 1791-7530 [Electronic] Greece
• PMID: 32620657 (Publication Type: Journal Article)
• Copyright: Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Antihypertensive Agents

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antihypertensive Agents (therapeutic use)
• Carcinoma, Renal Cell (epidemiology, pathology)
• Disease Progression
• Female
• Humans
• Hypertension (drug therapy, epidemiology)
• Kidney Neoplasms (epidemiology, pathology)
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• Retrospective Studies
• Risk Factors
• Tumor Burden
• Young Adult