Abstract | INTRODUCTION: METHODS: We performed a cross-sectional analysis of the Northern Manhattan Study-MRI Substudy. The associations between the rs738409 G variant allele and outcomes were assessed using linear regression for WMH volume, logistic regression for microbleeds and CBI, and Poisson regression for small perivascular spaces. Models were adjusted for age, sex, principal components, diabetes, and body mass index. RESULTS: We included 1063 Northern Manhattan Study participants who had brain MRI and genotype data available (mean age 70 ± 9 years, 61% women). The G allele frequency was 24%. The prevalence of any microbleeds and CBI were 8% and 18%, respectively. The median WMH volume and small perivascular space count score were 7.7 mL and 6, respectively. GG homozygosity, but not heterozygosity, was associated with WMH volume (β = 0.27; 95% CI, 0.03, 0.51) compared to non-carriers. Having at least one G allele was associated with the presence of microbleeds (Odds ratio, 1.78; 95% CI, 1.02, 3.12); the association was attenuated in other models. No associations were observed for CBI and small perivascular spaces. CONCLUSION: The PNPLA3 rs738409 G allele was associated with greater WMH volume, and inconsistent associations with microbleeds were seen.
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Authors | Neal S Parikh, Nicole Dueker, Dalila Varela, Victor J Del Brutto, Tatjana Rundek, Clinton B Wright, Ralph L Sacco, Mitchell S V Elkind, Jose Gutierrez |
Journal | Journal of the neurological sciences
(J Neurol Sci)
Vol. 416
Pg. 116981
(Sep 15 2020)
ISSN: 1878-5883 [Electronic] Netherlands |
PMID | 32592869
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- Membrane Proteins
- Lipase
- adiponutrin, human
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Topics |
- Aged
- Biomarkers
- Cross-Sectional Studies
- Female
- Genetic Predisposition to Disease
- Humans
- Lipase
(genetics)
- Magnetic Resonance Imaging
- Male
- Membrane Proteins
- Middle Aged
- Non-alcoholic Fatty Liver Disease
- Polymorphism, Single Nucleotide
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